Results
| PMID | 22563871 |
| Gene Name | PAEP |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 50 adolescent girls |
| Age | 13-19 years |
| Sex | Female |
| Associated genes | IL-6, TNF-alpha, glycodelin A |
| Other associated phenotypes |
Endometriosis |
|
J Obstet Gynaecol Res. 2012 Oct;38(10):1245-53. doi: Drosdzol-Cop, Agnieszka| Skrzypulec-Plinta, Violetta Woman's Health Institute and Medical University of Silesia, Katowice, Poland. cor111@poczta.onet.pl AIM: The aim of this study was to determine the role of serum and peritoneal interleukin (IL)-6, tumor necrosis factor (TNF)-alpha and glycodelin A levels as diagnostic markers of endometriosis in adolescent girls. MATERIAL AND METHODS: The study encompassed 50 adolescent girls, aged 13-19 years, after menarche and with chronic pelvic pain who qualified for diagnostic laparoscopy. The patients were allocated into two groups: group I (endometriosis group) consisted of subjects with diagnosed endometriosis (n = 33, 66%) and group II (control group) included those whose laparoscopic examinations revealed no evidence of endometriosis (n = 17, 34%). IL-6, TNF-alpha and glycodelin A concentrations in serum and peritoneal samples were assessed using commercially available human enzyme-linked immunosorbent assay kits. The value of P < 0.05 was adopted as the level of statistical significance. RESULTS: Compared with the control group, adolescent girls with endometriosis had significantly higher peritoneal fluid levels of: IL-6 (525.10 +/- 1168.53 pg/mL vs 62.96 +/- 82.35 pg/mL), TNF-alpha (5.79 +/- 5.60 pg/mL vs 1.68 +/- 1.24 pg/mL) and glycodelin A (94.24 +/- 60.97 ng/mL vs 53.52 +/- 41.43 ng/mL). Peritoneal IL-6, TNF-alpha and glycodelin A provided a good method of discrimination between subjects with endometriosis and controls. Using cut-off points for peritoneal fluid IL-6 (90.00 pg/mL), TNF-alpha (3.00 pg/mL) and glycodelin A (60.0 ng/mL), exceptionally high odds ratios (10.2; 14.6; 2.2) were obtained in the prediction of endometriosis in adolescents. CONCLUSIONS: At the cut-off value of 3.00 pg/mL, peritoneal TNF-alpha can be a reliable screening marker for the prediction of endometriosis in adolescents, giving a 14.6-fold higher probability of endometriosis detection in girls with chronic pelvic pain. Mesh Terms: Adolescent| Ascitic Fluid/*metabolism| Biomarkers/blood/metabolism| Early Diagnosis| Endometriosis/blood/diagnosis/*metabolism| Female| Glycodelin| Glycoproteins/blood/*metabolism| Humans| Interleukin-6/blood/*metabolism| Poland| Pregnancy Prot |
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